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Isolation of Nitrophenols from Diesel Exhaust Particles (DEP) as Vasodilatation Compounds

2003; Pharmaceutical Society of Japan; Volume: 26; Issue: 3 Linguagem: Inglês

10.1248/bpb.26.394

1347-5215

Yoki Mori, Kazuyuki Kamata, Noriko Toda, Hideyuki Hayashi, Koh‐ichi Seki, Shinji Taneda, Shin Yoshino, Akiyo Sakushima, Masakatsu Sakata, Akira K. Suzuki,

Atmospheric chemistry and aerosols

The compounds in diesel exhaust particles (DEP) that are responsible for vasodilatation were isolated and characterized for the first time. From benzene extract of DEP, 2-methyl-4-nitrophenol, 3-methyl-4-nitrophenl and 4-nitrophenol were isolated, and their vasodilatation activities were confirmed. 3-methyl-4-nitrophenol caused dilatation of rat thoracic artery, and the other two nitrophenols, also showed vasodilatation activities.