Synthetic studies on bryostatins, potent antineoplastic agents: Synthesis of the C17C27 fragment of C20 oxygenated bryostatins
1995; Elsevier BV; Volume: 36; Issue: 36 Linguagem: Inglês
10.1016/0040-4039(95)01310-e
ISSN1873-3581
AutoresKen Ohmori, Shigeru Nishiyama, Shosuke Yamamura,
Tópico(s)Asymmetric Synthesis and Catalysis
ResumoSynthetic process towards the bottom half portion of C20 oxygenated series of bryostatins is described. The stereogenic center at C20 position was constructed through a hydroxyl group-directed epoxidation by using mCPBA. It was found that silver (I) salt is an effective and mild reagent for regioselective ring cleavage of α-bromoepoxides into the corresponding α-hydroxyketones via oxonium ion intermediates.
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