A Convenient synthesis of the, conformationally constrained amino acid 5,5-dimethylproline
1993; Elsevier BV; Volume: 34; Issue: 3 Linguagem: Inglês
10.1016/0040-4039(93)85081-7
ISSN1873-3581
AutoresVictoria W. Magaard, Robert M. Sanchez, John W. Bean, M. Lane Moore,
Tópico(s)Peptidase Inhibition and Analysis
ResumoA convenient synthesis of Boc-DL-5,5-dimethylproline methyl ester is described. This conformationally-constrained amino acid may be expected to exist predominantly in the cis peptide bond isomer when into peptides. The peptide bond in the model peptide Boc-Phe-Me2Pro-OMe is shown to be 90% in the cis isomer.
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