STEREOCONTROLLED SYNTHESIS OF SEGMENTS FOR THE SYNTHESIS OF TYLONOLIDE BY USING A RELATIVE 1,2-ASYMMETRIC INDUCTION
1986; Oxford University Press; Volume: 15; Issue: 4 Linguagem: Inglês
10.1246/cl.1986.523
ISSN1348-0715
AutoresYasunori Kitano, Masato Kusakabe, Yuichi Kobayashi, Fumie Sato,
Tópico(s)Cancer Treatment and Pharmacology
ResumoAbstract Two precursors corresponding to the C(1)–C(9) and C(13)–C(17) portions of tylonolide were synthesized in which all the chiral centers were induced correctly from the only one stereocenter existing in 2-methy-3-trimethylsilylbut-3-enal and 2-benzyloxymethyl-3-trimethylsilylbut-3-enal, respectively.
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