Novel C 3 V -Symmetric Tripodal Scaffold, Triethyl cis,cis,cis- 2,5,8- Tribenzyltrindane-2,5,8-tricarboxylate, for the Construction of Artificial Receptors
2002; American Chemical Society; Volume: 4; Issue: 5 Linguagem: Inglês
10.1021/ol017294t
ISSN1523-7060
AutoresHeung‐Jin Choi, Yeon Sil Park, Seok Hun Yun, Kim Hong-Seok, Chan Sik Cho, Kwangnak Ko, Kyo Han Ahn,
Tópico(s)Advanced biosensing and bioanalysis techniques
Resumo[reaction: see text] A novel C3V-symmetric scaffold, trindane 7, has been efficiently synthesized from 1,3,5-tris(bromomethyl)-2,4,6-tris(chloromethyl)benzene (1) in six steps with 47% overall yield. The control of all-syn stereochemistry in the tribenzylation step has been achieved by blocking one side of the trindane ring as metal carbonyl complexes. The potential utility of trindane 7 as a receptor skeleton has been examined with a urea derivative 12 toward several anionic guests.
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