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Impact of antiretroviral dosing and daily pill burden on viral rebound rates in naive patients receiving a tenofovir-based regimen

2008; International AIDS Society; Volume: 11; Issue: Suppl 1 Linguagem: Inglês

10.1186/1758-2652-11-s1-p3

1758-2652

Adriana Ammassari, Patrizia Lorenzini, Franco Maggiolo, Gaetana Sterrantino, Angela Corpolongo, Giuliano Rizzardini, N Abrescia, Antonio Chirianni, Maria Foggia, Cristina Mussini, Nicola Gianotti, Massimo Andreoni, Carlo Federico Perno, Andrea Antinori,

HIV Research and Treatment

Methods A total of 480 ART-naive patients were selected from the GNOMO cohort. Incidence rate of viral rebound (VR = first of two consecutive VL>50 cp/ml) was calculated as number of events over PYFU and expressed at univariate and multivariate analysis as incidence rate ratio (IRR). Number of both pills and doses per day were used to define three different types of regimens: twice-a-day regimens (BID regimens); once-a-day regimens with 3 pills (high-pill QD [hp-QD]). Adjusted rates of viral rebound were estimated by Poisson regression using date of first HIV-RNA <50 c/ml as baseline. Follow-up was censored at the date of VR, death, or loss to follow-up.