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Targeting Ras and Rho GTPases as opportunities for cancer therapeutics

2004; Elsevier BV; Volume: 15; Issue: 1 Linguagem: Inglês

10.1016/j.gde.2004.11.001

1879-0380

Katharine Walker, Michael F. Olson,

Cancer-related Molecular Pathways

The Ras and Rho GTPases contribute to the initiation and progression of cancer by subverting the normal regulation of specific intracellular signalling pathways. As a result, Ras and Rho play significant roles in the development of numerous aspects of the malignant phenotype by promoting cell cycle progression, resistance to apoptotic stimuli, neo-vascularisation and tumour cell motility, invasiveness and metastasis. With these GTPases contributing at so many levels, they are appealing targets for the development of cancer chemotherapeutic agents.