Locally Synchronized Synaptic Inputs
2012; American Association for the Advancement of Science; Volume: 335; Issue: 6066 Linguagem: Inglês
10.1126/science.1210362
ISSN1095-9203
AutoresNaoya Takahashi, K. Kitamura, Naoki Matsuo, Mark Mayford, Masanobu Kano, Norio Matsuki, Yuji Ikegaya,
Tópico(s)Neural dynamics and brain function
ResumoSynaptic inputs on dendrites are nonlinearly converted to action potential outputs, yet the spatiotemporal patterns of dendritic activation remain to be elucidated at single-synapse resolution. In rodents, we optically imaged synaptic activities from hundreds of dendritic spines in hippocampal and neocortical pyramidal neurons ex vivo and in vivo. Adjacent spines were frequently synchronized in spontaneously active networks, thereby forming dendritic foci that received locally convergent inputs from presynaptic cell assemblies. This precise subcellular geometry manifested itself during N-methyl-D-aspartate receptor-dependent circuit remodeling. Thus, clustered synaptic plasticity is innately programmed to compartmentalize correlated inputs along dendrites and may reify nonlinear synaptic integration.
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