Spermine as a putative modulator of the N-methyl-D-aspartate (NMDA) receptors: Neurochemical and pharmacological properties
1992; Elsevier BV; Volume: 26; Linguagem: Inglês
10.1016/1043-6618(92)90978-k
ISSN1096-1186
AutoresCarmela Speciale, Luca Raimondi, L. Facheris, M. Marconi, Ruggero G. Fariello,
Tópico(s)Neuroendocrine regulation and behavior
ResumoPreviously, we have demonstrated that lateral habenula (LH) modulates the bioelectric activity of the hippocampus through the dorsal raphe nucleus functional involvement. In this study we have, preliminarily, electrophysiologically identified two types of raphe neurons: “slow” (S cells, serotonergic in nature); and “fast” (F cells, presumably GABAergic in nature). Then, we have shown that LH electrical stimulation at lower frequency induced an excitation of S and F neurons. LH stimulation at higher frequency inhibited only S neurons. Furthermore, iontophoretic NMDA excited S and F neurons. The excitatory effects of LH stimulation were antagonized by the iontophoretic 2-APV (NMDA antagonist). Iontophoretic GABA inhibited only S neurons. Iontophoretic bicuculline antagonized the LH-induced inhibition of S neurons. The data suggested a direct (NMDA-mediated) and indirect (through the F GABAergic inhibitory interneuron) influence of the LH on the serotonergic efferent neuron.
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