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Blood pressure effects of thyrotropin-releasing hormone and epinephrine in anaphylactic shock

1988; Elsevier BV; Volume: 17; Issue: 4 Linguagem: Inglês

10.1016/s0196-0644(88)80768-6

1097-6760

Robert L. Muelleman, John P. Pribble, Joseph A. Salomone,

Neuropeptides and Animal Physiology

To compare the effects of a single dose of thyrotropin-releasing hormone (TRH), epinephrine, and control (normal saline) on mean arterial pressure (MAP) and survival over a one-hour observation period, we carried out a randomized, blinded study using a rabbit model of anaphylaxis. Epinephrine resulted in an increased MAP over normal saline and TRH at one minute after treatment (P < .001). TRH resulted in an increased MAP over normal saline at two minutes (P < .017) and over epinephrine at four minutes (P < .011) after treatment. No differences in MAP were detected beyond four minutes after treatment. There was no difference in survival between treated and control animals (α < .168). Although no difference in survival existed, TRH had a slower onset, but more sustained effect on MAP than did epinephrine and normal saline. To compare the effects of a single dose of thyrotropin-releasing hormone (TRH), epinephrine, and control (normal saline) on mean arterial pressure (MAP) and survival over a one-hour observation period, we carried out a randomized, blinded study using a rabbit model of anaphylaxis. Epinephrine resulted in an increased MAP over normal saline and TRH at one minute after treatment (P < .001). TRH resulted in an increased MAP over normal saline at two minutes (P < .017) and over epinephrine at four minutes (P < .011) after treatment. No differences in MAP were detected beyond four minutes after treatment. There was no difference in survival between treated and control animals (α < .168). Although no difference in survival existed, TRH had a slower onset, but more sustained effect on MAP than did epinephrine and normal saline.