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Use of dried blood spots to study excipient kinetics in neonates

2011; Future Science Ltd; Volume: 3; Issue: 24 Linguagem: Inglês

10.4155/bio.11.277

1757-6199

Shirish Yakkundi, James C. McElnay, Jeff S. Millership, Hussain Mulla, Hitesh Pandya, Utpal Shah, Tony Nunn, André Rieutord, Thomas Storme, Pascal Vaconsin, Tuuli Metsvaht, Heili Varendi, Georgi Nellis, Irja Lutsar, M. Turner,

Biosimilars and Bioanalytical Methods

BioanalysisVol. 3, No. 24 Special Focus: Reid Bioanalytical Forum - EditorialUse of dried blood spots to study excipient kinetics in neonatesShirish Yakkundi, James McElnay, Jeff Millership, Hussain Mulla, Hitesh Pandya, Utpal Shah, Tony Nunn, Andre Rieutord, Thomas Storme, Pascal Vaconsin, Tuuli Metsvaht, Heili Varendi, Georgi Nellis, Irja Lutsar & Mark TurnerShirish Yakkundi* Author for correspondence, James McElnayClinical & Practice Research Group, School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland, UK, Jeff MillershipClinical & Practice Research Group, School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland, UK, Hussain MullaUniversity of Leicester, Leicester, UK, Hitesh PandyaUniversity of Leicester, Leicester, UK, Utpal ShahAlder Hey Children's NHS Foundation Trust, Liverpool, UK, Tony NunnAlder Hey Children's NHS Foundation Trust, Liverpool, UK, Andre RieutordAssistance Publique Hôpitaux de Paris - Hôpital Antoine Béclère, Clamart, France, Thomas StormeAssistance Publique Hôpitaux de Paris - Hôpital Robert Debré, Paris, France, Pascal VaconsinAssistance Publique Hôpitaux de Paris - Hôpital Robert Debré, Paris, France, Tuuli MetsvahtUniversity of Tartu, Tartu, Estonia, Heili VarendiUniversity of Tartu, Tartu, Estonia, Georgi NellisUniversity of Tartu, Tartu, Estonia, Irja LutsarUniversity of Tartu, Tartu, Estonia & Mark TurnerWomen's & Children's Health, University of Liverpool, Liverpool, UKPublished Online:20 Dec 2011https://doi.org/10.4155/bio.11.277AboutSectionsView ArticleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinkedInReddit View articleKeywords: dried blood spotsESNEEexcipient kineticsexcipientsLC–MS/MSneonatespopulation pharmacokineticsReferences1 LeBel M, Ferron L, Masson M, Pichette J, Carrier C. 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Bioanalysis2(6),1051–1072 (2010).Link, CAS, Google ScholarFiguresReferencesRelatedDetailsCited ByHematocrit, blood volume, and surface area of dried blood spots – a quantitative modelDrug Testing and Analysis, Vol. 12, No. 4Safety, dosing, and pharmaceutical quality for studies that evaluate medicinal products (including biological products) in neonates3 November 2016 | Pediatric Research, Vol. 81, No. 5Neonatal medicines research: challenges and opportunities10 May 2015 | Expert Opinion on Drug Metabolism & Toxicology, Vol. 11, No. 7An Observational Study of Blood Concentrations and Kinetics of Methyl- and Propyl-Parabens in Neonates19 September 2014 | Pharmaceutical Research, Vol. 32, No. 3Excipients in Pediatric Formulations: Biopharmaceutical and Toxicological Considerations20 September 2015Application of Dried Blood Spot Sampling in Clinical Pharmacology Trials and Therapeutic Drug Monitoring13 June 2014Risk assessment of neonatal excipient exposure: Lessons from food safety and other areasAdvanced Drug Delivery Reviews, Vol. 73European Study of Neonatal Exposure to Excipients: An updateInternational Journal of Pharmaceutics, Vol. 457, No. 1Hospitalised neonates in Estonia commonly receive potentially harmful excipients29 August 2012 | BMC Pediatrics, Vol. 12, No. 1Conference Report: The 19th International Reid Bioanalytical ForumHoward Hill20 December 2011 | Bioanalysis, Vol. 3, No. 24 Vol. 3, No. 24 STAY CONNECTED Metrics Downloaded 327 times History Published online 20 December 2011 Published in print December 2011 Information© Future Science LtdKeywordsdried blood spotsESNEEexcipient kineticsexcipientsLC–MS/MSneonatespopulation pharmacokineticsFinancial & competing interests disclosureThe ESNEE project has been funded via the European Research Area-Network PRIOMEDCHILD program. In the UK this is supported by Medical Reseach Council grant number G1100158. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.No writing assistance was utilized in the production of this manuscript.PDF download