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Liver Dysfunction and Phosphatidylinositol-3-Kinase Signalling in Early Sepsis: Experimental Studies in Rodent Models of Peritonitis

2012; Public Library of Science; Volume: 9; Issue: 11 Linguagem: Inglês

10.1371/journal.pmed.1001338

1549-1676

Peter Recknagel, Falk A. Gonnert, Martin Westermann, Sandro Lambeck, Amelie Lupp, Alain Rudiger, Alex Dyson, Jane E. Carré, Andreas Kortgen, Christoph Krafft, Jürgen Popp, Christoph Sponholz, Valentin Fuhrmann, Ingrid Hilger, Ralf A. Claus, Niels C. Riedemann, Reinhard Wetzker, Mervyn Singer, Michael Trauner, Michael Bauer,

Liver Disease Diagnosis and Treatment

Experimental studies in a rat model of fecal peritonitis conducted by Michael Bauer and colleagues show that in this model, changes in liver function occur early in the development of sepsis, with potential implications for prognosis and development of new therapeutic approaches.