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Retention of brodifacoum in sheep tissues and excretion in faeces

1985; Taylor & Francis; Volume: 28; Issue: 3 Linguagem: Inglês

10.1080/00288233.1985.10430438

1175-8775

F. J. Laas, D. A. Forss, M. E. R. Godfreyi,

Forensic Entomology and Diptera Studies

Abstract The anticoagulant, brodifacoum, is currently being evaluated for poisoning rabbits on New Zealand sheep grazing lands. Because of possible carcass contamination risks, the retention and excretion characteristics of the compound when ingested by sheep were determined. Two groups of 7 sheep each were dosed with brodifacoum at 2.0 and 0.2 mg/kg Iiveweight respectively, after a pilot study had determined brodifacoum distribution. Animals were killed at 2, 4, 8, 15, 32, 64, or 128 days after dosing, and liver, carcass, and omental fat sampled. Faeces were collected daily from some of the sheep. Brodifacoum was detected in omental fat for up to 8 days, and in the carcass up to 15 days after dosing. It was still present in the liver at both dose levels after 128 days. At the 2.0 mg/kg dose level, liver brodifacoum residues fell from 6.5 mg/kg dry matter (DM) at 2 days to 1.1 mg/kg DM at 128 days. About 33% of the 2.0 mg/kg dose and 20% of the 0.2 mg/kg dose was recovered from faeces in the first 8 days. None was detectable in faeces 64 days after dosing. At present, brodifacoum is not being used where it could be ingested by food producing animals in New Zealand.