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On the functional role of coexistence of 5‐HT and substance P in bulbospinal 5‐HT neurons. Substance P reduces affinity and increases density of 3 H‐5‐HT binding sites

1983; Wiley; Volume: 117; Issue: 2 Linguagem: Inglês

10.1111/j.1748-1716.1983.tb07210.x

1365-201X

Luigi F. Agnati, Kjell Fuxé, Fabio Benfenati, I. Zini, Tomas Hökfelt,

Pain Mechanisms and Treatments

Acta Physiologica ScandinavicaVolume 117, Issue 2 p. 299-301 On the functional role of coexistence of 5-HT and substance P in bulbospinal 5-HT neurons. Substance P reduces affinity and increases density of 3H-5-HT binding sites LUIGI F. AGNATI, LUIGI F. AGNATI Departments of Human Physiology and Endocrinology, University of Modena, Italy, and Department of Histology, Karolinska Institutet, Stockholm, SwedenSearch for more papers by this authorKJELL FUXE, KJELL FUXE Departments of Human Physiology and Endocrinology, University of Modena, Italy, and Department of Histology, Karolinska Institutet, Stockholm, SwedenSearch for more papers by this authorFABIO BENFENATI, FABIO BENFENATI Departments of Human Physiology and Endocrinology, University of Modena, Italy, and Department of Histology, Karolinska Institutet, Stockholm, SwedenSearch for more papers by this authorISABELLA ZINI, ISABELLA ZINI Departments of Human Physiology and Endocrinology, University of Modena, Italy, and Department of Histology, Karolinska Institutet, Stockholm, SwedenSearch for more papers by this authorTOMAS HÖKFELT, TOMAS HÖKFELT Departments of Human Physiology and Endocrinology, University of Modena, Italy, and Department of Histology, Karolinska Institutet, Stockholm, SwedenSearch for more papers by this author LUIGI F. AGNATI, LUIGI F. AGNATI Departments of Human Physiology and Endocrinology, University of Modena, Italy, and Department of Histology, Karolinska Institutet, Stockholm, SwedenSearch for more papers by this authorKJELL FUXE, KJELL FUXE Departments of Human Physiology and Endocrinology, University of Modena, Italy, and Department of Histology, Karolinska Institutet, Stockholm, SwedenSearch for more papers by this authorFABIO BENFENATI, FABIO BENFENATI Departments of Human Physiology and Endocrinology, University of Modena, Italy, and Department of Histology, Karolinska Institutet, Stockholm, SwedenSearch for more papers by this authorISABELLA ZINI, ISABELLA ZINI Departments of Human Physiology and Endocrinology, University of Modena, Italy, and Department of Histology, Karolinska Institutet, Stockholm, SwedenSearch for more papers by this authorTOMAS HÖKFELT, TOMAS HÖKFELT Departments of Human Physiology and Endocrinology, University of Modena, Italy, and Department of Histology, Karolinska Institutet, Stockholm, SwedenSearch for more papers by this author First published: February 1983 https://doi.org/10.1111/j.1748-1716.1983.tb07210.xCitations: 83AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL REFERENCES AGNATI, L. F., FUXE, K., ZINI, I., LENZI, P. & HÖKFELT, T. 1980. Aspects on receptor regulation and isoreceptor identification. Med Biol 58: 182– 187. BENNETT, J. P. & SNYDER, S. H. 1976. Serotonin and lysergic acid diethylamide binding in rat brain membranes: relationship to postsynaptic receptor. Molec Pharmacol 12: 373– 389. CHANGEUX, J. -P. 1979. Some principles of neuronal regulation at the postsynaptic level. In: Central regulation of the endocrine systems (ed. K. Fuxe, T. Hökfelt & R. Luft), pp. 489– 505. Plenum Press, New York . HÖKFELT, T., LJUNGDAHL, Å., STEINBUCH, H., VERHOFSTAD, A., NILSSON, G., BRODIN, F., PERNOW, B. & GOLDSTEIN, M. 1978. Immunohis-tochemical evidence of substance P immunoreactivity in some 5-hydroxytryptamine containing neurons in the rat central nervous system. Neurosci 3: 517– 538. LEFKOWITZ, R. J. 1980. Radioligand binding studies of adrenergic receptors. In: Central adrenaline neurons. Basic aspects and their role in cardiovascular functions (ed. K. Fuxe, M. Goldstein, B. Hökfelt & T. Hökfelt), pp. 291– 301. Pergamon Press, Oxford , 1980. NELSON, D. L., HERBERG, A., BOURGOIN, S., GLOWINSKI, J. & HANON, M. 1978. Characteristics of central 5-HT receptors and their adaptive changes following intracerebral 5, 7-dihydroxytryptamine administration in the rat. Molec Pharmacol 14: 983– 995. ROSELL, S., OLGART, L., GAZELIUS, B., PANOPOULOS, P., FOLKERS, K. & HÖRIG, J. 1981. Inhibition of antidromic and substance P-induced vasodilatation by a substance P antagonist. Acta Physiol Scand 111: 381– 382. Citing Literature Volume117, Issue2February 1983Pages 299-301 ReferencesRelatedInformation