Inhibition of Hyperalgesia by Ablation of Lamina I Spinal Neurons Expressing the Substance P Receptor
1997; American Association for the Advancement of Science; Volume: 278; Issue: 5336 Linguagem: Inglês
10.1126/science.278.5336.275
ISSN1095-9203
AutoresPatrick W. Mantyh, Scott D. Rogers, Prisca Honoré, Brian Allen, Joseph R. Ghilardi, Jun Li, Randy S. Daughters, Douglas A. Lappi, Ronald G. Wiley, Donald A. Simone,
Tópico(s)Neuropeptides and Animal Physiology
ResumoSubstance P is released in the spinal cord in response to painful stimuli, but its role in nociceptive signaling remains unclear. When a conjugate of substance P and the ribosome-inactivating protein saporin was infused into the spinal cord, it was internalized and cytotoxic to lamina I spinal cord neurons that express the substance P receptor. This treatment left responses to mild noxious stimuli unchanged, but markedly attenuated responses to highly noxious stimuli and mechanical and thermal hyperalgesia. Thus, lamina I spinal cord neurons that express the substance P receptor play a pivotal role in the transmission of highly noxious stimuli and the maintenance of hyperalgesia.
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