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Artigo Produção Nacional Revisado por pares
BIBTEX RIS

Coordination to gallium(III) strongly enhances the potency of 2-pyridineformamide thiosemicarbazones against Cryptococcus opportunistic fungi

2009; Elsevier BV; Volume: 165; Issue: 7 Linguagem: Inglês

10.1016/j.micres.2009.10.005

ISSN

1618-0623

Autores

Thaíssa de Oliveira Bastos, Betânia Maria Soares, Patrícia Silva Cisalpino, Isolda C. Mendes, Raquel Gouvêa dos Santos, Heloísa Beraldo,

Tópico(s)

Antifungal resistance and susceptibility

Resumo

A family of 2-pyridineformamide-derived thiosemicarbazones and their gallium(III) complexes were tested against several isolates of pathogenic Cryptococcus strains. On complexation the antifungal activity significantly increases, suggesting coordination to gallium(III) to be an interesting strategy of antifungal dose reduction.

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