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Diverse Effects of the Guanine Nucleotide Exchange Factor RCC1 on RNA Transport

1995; American Association for the Advancement of Science; Volume: 267; Issue: 5205 Linguagem: Inglês

10.1126/science.7534442

1095-9203

Yan Cheng, James E. Dahlberg, Elsebet Lund,

RNA regulation and disease

Transport of RNAs within nuclei and through nuclear pore complexes (NPCs) are essential, but poorly understood, steps in gene expression. In experiments with mammalian cells, RCC1, the abundant nuclear guanine nucleotide exchange factor for the guanosine triphosphatase Ran/TC4, was shown to be required for nucleocytoplasmic transport of precursors of spliceosomal small nuclear RNAs (snRNAs), intranuclear transport of U3 snRNA, and processing of ribosomal RNAs, but not for export of transfer RNAs. It is proposed that guanosine triphosphate (GTP)-bound Ran/TC4 associates with ribonucleoprotein particles (RNPs) during intranuclear movement, and that GTP hydrolysis promotes deposition of RNPs at targeted sites such as NPCs or nucleoli.