Role of Transforming Growth Factor-β in Repair and Fibrosis
1991; Elsevier BV; Volume: 99; Issue: 3 Linguagem: Inglês
10.1378/chest.99.3_supplement.61s
ISSN1931-3543
Autores Tópico(s)Tendon Structure and Treatment
ResumoFollowing acute injuries caused by physical (eg, radiation or heat), toxic, or immunologic agents, a complex process of tissue regeneration and repair is initiated at the site of the lesion. This process of wound healing involves complex cellular and molecular interactions and in some ways recapitulates events commonly encountered during embryonic organogenesis. 1 Ten Dijke P Iwata KK Growth factors for wound healing. Biotechnology. 1989; 7: 793-798 Crossref Scopus (82) Google Scholar Mechanistic details of the processes that govern molecular and cellular interactions during tissue regeneration and fibrosis have been elucidated by investigations of incisional wounds of skin and by studies of the various models of pulmonary and hepatic fibrosis. These studies have firmly established a central role for various growth factors and cytokines in the process of tissue regeneration and repair. The most intensively studied growth factors in this regard are epidermal growth factor (EGF), platelet-derived growth factor (PDGF), fibroblast growth factor (FGF), and transforming growth factor-β (TGF-β). These investigations have provided strong support for the concept that the same processes that underlie tissue regeneration and repair, leading to complete restoration of normal tissue function, are also intimately linked to excessive scar formation and fibrosis. Thus, it is generally believed that the processes of wound healing and fibrosis are 2 sides of the same coin.
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