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Clinical Risk Factors for Primary Graft Dysfunction after Lung Transplantation

2013; Elsevier BV; Volume: 32; Issue: 4 Linguagem: Inglês

10.1016/j.healun.2013.01.911

1557-3117

Joshua M. Diamond, J.C. Lee, Steven M. Kawut, Rupal J. Shah, A. Russell Localio, Scarlett L. Bellamy, Edward Cantu, David J. Lederer, Benjamin Kohl, Vibha N. Lama, Sangeeta Bhorade, M. Crespo, E. Demissie, Joshua Sonett, Keith Wille, Jonathan B. Orens, Ashish S. Shah, Ann Weinacker, Selim M. Arcasoy, Pali D. Shah, David S. Wilkes, Lorraine B. Ware, Scott M. Palmer, Jason D. Christie,

Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis

association of high reperfusion FiO2 (Z0.40) with PGD (p¼0.008,Figure).Conclusions: High pre-op levels of plasma freeHgb associate with PGD, particularly when FiO2 is high at reperfusion.FreeHgb may be a mediator of oxidative injury during ischemia reperfusion and high levels of inspired O2 may potentiate this oxidative injury.