A Novel Insulin Delivery Algorithm in Rats With Type 1 Diabetes: The Fading Memory Proportional‐Derivative Method
2005; Wiley; Volume: 29; Issue: 8 Linguagem: Inglês
10.1111/j.1525-1594.2005.29096.x
ISSN1525-1594
AutoresBala Gopakumaran, Heather M. Duman, Douglas P. Overholser, Isaac F. Federiuk, Matthew J. Quinn, Michael D. Wood, W. Kenneth Ward,
Tópico(s)Receptor Mechanisms and Signaling
ResumoAn algorithm designed to automatically control insulin delivery was tested in rats with Type 1 diabetes. This nonlinear algorithm included a fading memory component of proportional and derivative errors in order to simulate normal insulin secretion. Error-weighting functions for the proportional and derivative terms were used with a performance index designed for error adaptation. In the first version of the algorithm, the proportional gain was adaptively varied. In the second version, a low rate of basal insulin delivery was adaptively varied. Six 6-h studies with each version were conducted using frequent blood sampling and intravenous insulin delivery. In Version 2 studies, blood glucose levels during the last two hours were well-controlled and significantly lower than in Version 1 (118 +/- 2.0 vs. 130 +/- 2.9 mg/dL). Neither version produced hypoglycemia. Future research using this algorithm needs to focus on automated glucose sensing in combination with insulin delivery.
Referência(s)