Long-Chain Polyunsaturated Fatty Acid Composition of Breast Milk in Pre-Eclamptic Mothers
2009; Karger Publishers; Volume: 97; Issue: 3 Linguagem: Inglês
10.1159/000252971
ISSN1661-7819
AutoresKamini Dangat, Savita Mehendale, Hemlata R. Yadav, Anitha S. Kilari, Asmita Kulkarni, Vaishali Taralekar, Sadhana Joshi,
Tópico(s)Breastfeeding Practices and Influences
Resumo<i>Background:</i> Maternal fatty acid nutrition during pregnancy and lactation determines the transfer of long-chain polyunsaturated fatty acids via the placenta and through human milk. Neural maturation of breast-fed infants is known to be linked to breast-milk long-chain polyunsaturated fatty acid concentrations. In spite of this, the fatty acid composition of breast milk in pre-eclamptic mothers is poorly understood. <i>Objectives:</i> To compare the fatty acid composition of breast milk of pre-eclamptic (n = 45) with normotensive (n = 85) mothers and examine the association of breast-milk fatty acids with plasma fatty acids. <i>Methods:</i> Milk and plasma fatty acid methyl esters were prepared and analyzed by the modified method of Manku and colleagues using gas chromatography. <i>Results:</i> Docosahexaenoic acid (DHA) concentrations were significantly increased (p < 0.01) in breast milk in spite of lower maternal plasma DHA concentrations (p < 0.05) in pre-eclamptic women. However, there was no difference in arachidonic acid levels between groups in spite of reduced maternal plasma arachidonic acid levels. <i>Conclusions:</i> The data suggest that in pre-eclampsia, the relation between plasma and milk DHA is altered. The resulting higher milk DHA concentrations are beneficial for infants.
Referência(s)