Produção Nacional
Revisado por pares
Synthesis, antioxidant and photoprotection activities of hybrid derivatives useful to prevent skin cancer
2014; Elsevier BV; Volume: 22; Issue: 9 Linguagem: Inglês
10.1016/j.bmc.2014.03.017
ISSN1464-3391
AutoresJuliana Santana Reis, Marcos Antônio Corrêa, Chung Man Chin, Jean Leandro dos Santos,
Tópico(s)Antioxidant Activity and Oxidative Stress
ResumoChronic ultraviolet (UV) radiation exposure is a major cause of skin cancer. A novel series of hybrid derivatives (I–VIII) for use in sunscreen formulations were synthesized by molecular hybridization of t-resveratrol, avobenzone, and octyl methoxycinnamate, and were characterized. The antioxidant activity values for VIII were comparable than to those of t-resveratrol. Compounds I–III and VI demonstrated Sun Protector Factor superior to that of t-resveratrol. Compounds I and IV–VIII were identified as new, broad-spectrum UVA filters while II–III were UVB filters. In conclusion, novel hybrid derivatives with antioxidant effects have emerged as novel photoprotective agents for the prevention of skin cancer.
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