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Mixed epithelial and stromal tumour of the kidney with luteinised ovarian stroma

2007; BMJ; Volume: 60; Issue: 1 Linguagem: Inglês

10.1136/jcp.2005.031294

1472-4146

C. Buriticá, María Magdalena Gea, A Zuluaga, María del Carmen Leiva Arrabal, Sigrid Regauer, Francisco F. Nogales,

Genetic and Kidney Cyst Diseases

We report a case of a 9-cm mixed epithelial and stromal tumour of the kidney in an obese 70-year-old woman with diabetes. The ovarian-type stroma had a spindle cell component that was positive for progesterone receptors and had the hitherto unreported presence of abundant foci of luteinised stromal cells with characteristic immunohistochemical positivity to α-inhibin, calretinin, aromatase and gonadotropin-releasing hormone (GnRH) receptors. We conclude that the stromal component is identical to ovarian cortical stroma. We believe that ovarian-type stroma occurs in extragenital tumours as a result of an epithelial–stromal interaction in an environment of hormonal hyperstimulation.