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Functional Magnetic Resonance Imaging of Human Brain Activation During Cue-Induced Cocaine Craving

1998; American Psychiatric Association; Volume: 155; Issue: 1 Linguagem: Inglês

10.1176/ajp.155.1.124

1535-7228

Luis C. Maas, Scott E. Lukas, Marc J. Kaufman, Roger D. Weiss, Sarah Daniels, Veronica Rogers, Thellea J. Kukes, Perry F. Renshaw,

Neuroscience and Neuropharmacology Research

Functional magnetic resonance imaging (MRI) was used to test whether brain activation was detectable in regions previously associated with cocaine cue-induced craving.Blood oxygenation level dependent (BOLD) functional activation was measured during presentation of audiovisual stimuli containing alternating intervals of drug-related and neutral scenes to six male subjects with a history of crack cocaine use and six male comparison subjects.Significant activation was detected in the anterior cingulate and left dorsolateral prefrontal cortex in the cocaine-using group. In addition, a correlation between self-reported levels of craving and activation in these regions was found.These results suggest that functional MRI may be a useful tool to study the neurobiological basis of cue-induced craving.