Iridium-catalyzed isomerization of primary allylic alcohols under mild reaction conditions
2009; Elsevier BV; Volume: 50; Issue: 28 Linguagem: Inglês
10.1016/j.tetlet.2009.04.130
ISSN1873-3581
Autores Tópico(s)Catalytic Cross-Coupling Reactions
ResumoThe isomerization of primary allylic alcohols into the corresponding aldehydes has been accomplished using an analogue of Crabtree's iridium hydrogenation catalyst and by adequately tuning the experimental conditions. A wide range of substrates is converted quantitatively into the desired aldehyde at room temperature in expedient reaction times by using catalyst loading as low as 0.25 mol %.
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