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Altered reproductive endocrine regulation in men with epilepsy: Implications for reproductive function and seizures

2002; Wiley; Volume: 51; Issue: 5 Linguagem: Inglês

10.1002/ana.10230

1531-8249

Andrew G. Herzog,

Pregnancy and Medication Impact

Annals of NeurologyVolume 51, Issue 5 p. 539-542 Editorial Altered reproductive endocrine regulation in men with epilepsy: Implications for reproductive function and seizures Andrew G. Herzog MD, MSc, Andrew G. Herzog MD, MSc Beth Israel Deaconess Medical Center, Boston, MassachusettsSearch for more papers by this author Andrew G. Herzog MD, MSc, Andrew G. Herzog MD, MSc Beth Israel Deaconess Medical Center, Boston, MassachusettsSearch for more papers by this author First published: 23 April 2002 https://doi.org/10.1002/ana.10230Citations: 33Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL References 1 Herzog AG, Seibel MM, Schomer DL, et al. Reproductive endocrine disorders in men with partial seizures of temporal lobe origin. Arch Neurol 1986; 43: 347– 350. 2 Herzog AG, Levesque LA. Testosterone, free testosterone, non SHBG-bound testosterone and free androgen index: which testosterone measurement is most relevant to reproductive and sexual function in men with epilepsy? Arch Neurol 1992; 49: 133– 134. 3 Stoffel-Wagner B, Bauer J, Flugel D, et al. Serum sex hormones are altered in patients with chronic temporal lobe epilepsy receiving anticonvulsant medication. Epilepsia 1998; 39: 1164– 1173 4 Herzog AG, Frye CA, Drislane FW, et al. Neuroactive reproductive steroid changes in men with epilepsy: associations with sexual function and potential implications for neuronal excitability. Epilepsia 2001; 42:(suppl 7): 297. 5 Rodin E, Subramanian MG, Gilroy J. Investigation of sex hormones in male epileptic patients. Epilepsia 1984; 25: 690– 694. 6 Isojarvi JI, Repo M, Pakarinen AJ, et al. Carbamazepine, phenytoin, sex hormones, and sexual function in men with epilepsy. Epilepsia 1995; 36: 366– 370. 7 Morrell MJ, Sperling MR, Stecker M, Dichter MA. 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Serum sex hormone levels after replacing carbamazepine with oxcarbazepine. Eur J Clin Pharmacol 1995; 47: 461– 464. 31 Herzog AG. A hypothesis to integrate partial seizures of temporal lobe origin and reproductive endocrine disorders. Epilepsy Res 1989; 3: 51– 159. 32 Knobil E. The GnRH pulse generator. Am J Obstet Gynecol 1990; 163: 1721– 1727. 33 Edwards HE, McIntyre Burnham W, MacLusky NJ. Partial and generalized seizures affect reproductive physiology differentially in the male rat. Epilepsia 1999; 40: 1490– 1498. 34 Silveira DC, Liu Z, de la Calle S, et al. Activation of the locus coeruleus following amygdaloid kindling. Epilepsia 1998; 39: 1261– 1264. 35 Friedman MN, Geula CG, Holmes GL, Herzog AG. Hypothalamic GnRH immunoreactive changes with unilateral amygdaloid kindling in female rats. Epilepsia 2000; 41: A30. 36 Sanches MA, Domingues R. Differential effects of unilateral lesions in the medial amygdala on spontaneous and induced ovulation. 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Interictal and postictal alterations of pulsatile secretion of luteinizing hormone in temporal lobe epilepsy in men. Ann Neurol 51: 559– 566. 45 Herzog AG, Coleman AE, Jacobs AR, et al. Acute hypothalamopituitary dysfunction following unilateral epileptiform discharges in women with epilepsy. Epilepsia 2000; 41: A167. 46 Saper CB, Loewy AD, Swanson LW, Cowan WM. Direct hypothalamo-autonomic connections. Brain Res 1976; 305– 312. 47 Gerendai I, Csaba Z, Voko Z, Csernus V. Involvement of a direct neural mechanism in the control of gonadal functions. J Steroid Biochem Mol Biol 1995; 53: 299– 305 48 Pouliot WA, Handa RJ, Beck SG. Androgen modulates N-methyl-D-aspartate-mediated depolarization in CA1 hippocampal pyramidal cells. Synapse 1996; 23: 10– 19. 49 Frye CA, Rhodes ME, Walf AA, Harney JP. Testosterone reduces pentylenetetrazole-induced ictal activity of wild type mice but not those deficient in type I 5α-reductase. Brain Res 2001; 918: 182– 186. 50 Herzog AG, Klein P, Jacobs AR. Testosterone versus testosterone and testolactone in treating reproductive and sexual dysfunction in men with epilepsy and hypogonadism. Neurology 1998; 50: 782– 784. Citing Literature Volume51, Issue5May 2002Pages 539-542 ReferencesRelatedInformation