Produção Nacional
Revisado por pares
In-vitro and in-vivo antitumour activity of physalins B and D from Physalis angulata
2006; Oxford University Press; Volume: 58; Issue: 2 Linguagem: Inglês
10.1211/jpp.58.2.0011
ISSN2042-7158
AutoresHemerson Iury Ferreira Magalhães, Márcia Rocha Torres, Letícia V. Costa‐Lotufo, Manoel Odorico de Moraes, Cláudia Pessoa, Maria Leopoldina Veras, Otília Deusdênia Loiola Pessoa, Edilberto R. Silveira, Ana Paula Negreiros Nunes Alves,
Tópico(s)Food Science and Nutritional Studies
ResumoAbstract We have evaluated the in-vitro and in-vivo antitumour activity of physalin B and physalin D isolated from the aerial parts of Physalis angulata. In-vitro, both compounds displayed considerable cytotoxicity against several cancer cell lines, showing IC50 values in the range of 0.58 to 15.18 μg mL−1 for physalin B, and 0.28 to 2.43 μg mL−1 for physalin D. The antitumour activity of both compounds was confirmed in-vivo using mice bearing sarcoma 180 tumour cells. The in-vivo antitumour activity was related to the inhibition of tumour proliferation, as observed by the reduction of Ki67 staining in tumours of treated animals. Histopathological examination of the kidney and liver showed that both organs were affected by physalin treatment, but in a reversible manner. These compounds were probably responsible for the previously described antitumour activity of ethanol extracts of P. angulata, and their identification and characterization presented here could explain the ethnopharmacological use of this species in the treatment of cancer.
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