The synthesis and cellular roles of phosphatidylinositol 4,5-bisphosphate
1998; Elsevier BV; Volume: 10; Issue: 2 Linguagem: Inglês
10.1016/s0955-0674(98)80148-8
ISSN1879-0410
Autores Tópico(s)Cell death mechanisms and regulation
ResumoPhosphatidylinositol 4,5-bisphosphate (PtdIns 4,5-P2) is a membrane phospholipid found in all eukaryotic cells which regulates many important cellular processes, including organization of the cytoskeleton, vesicular trafficking and platelet activation. PtdIns 4,5-P2 can either act as a substrate for lipid kinases and phosphatases, or directly interact with proteins. Recent work has focused on the characterization of the enzymes that regulate PtdIns 4,5-P2 levels in the cell. The discovery of proteins whose activities are modified by interaction with PtdIns 4,5-P2 has helped to redefine the role of this lipid in cell biology.
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