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URINARY FIBRIN/FIBRINOGEN DEGRADATION PRODUCTS (FDP) AND GLOMERULONEPHRITIS

1974; Wiley; Volume: 195; Issue: 1-6 Linguagem: Inglês

10.1111/j.0954-6820.1974.tb08101.x

0001-6101

Ulla Hedner, Mats Ekberg, Inga Marie Nilsson,

Muscle and Compartmental Disorders

Abstract. In concentrated 24‐hour urine from 24 patients with incipient glomerulonephritis without uraemia the fibrin/fibrinogen degradation products (FDP) have been studied. In 18 of 19 patients with proliferative glomerulonephritis high molecular weight degradation products (HMWDP) were found, while one patient had D and E products probably due to further degradation of the HMWDP in the lower urinary tract. Only 2 patients of 5 with membranous glomerulonephritis had HMWDP in the urine in low concentrations. All patients with proliferative glomerulonephritis had a selective proteinuria with an excretion predominantly of albumin and transferrin, which makes it improbable that the HMWDP found in the urine from these patients are derived from filtration through the glomeruli. Thus the urinary HMWDP found in these patients most probably originate from lysis of fibrin deposits in the kidney and are excreted in the urine. It is concluded that the FDP may be demonstrated in the urine also in incipient glomerulonephritis provided that the urine is concentrated. These FDP most probably originate from the kidneys.