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Cembrane Diterpenes from the Gorgonian Lophogorgia peruana

2006; American Chemical Society; Volume: 69; Issue: 12 Linguagem: Inglês

10.1021/np060388x

1520-6025

Marianela Sánchez, Marı́a J. Ortega, Eva Zubı́a, José Luís Carballo,

Marine Toxins and Detection Methods

The chemical study of the gorgonian Lophogorgia peruana collected at the Gulf of California has led to the isolation of the new diterpenes lophodienone (2), lophodiol A (3), lophodiol B (4), 17-acetoxylophotoxin (5), 15,16-epoxylophotoxin (6), 17-acetoxy-15,16-epoxylophotoxin (7), and isoepoxylophodione (8), together with the known compounds lophotoxin (1), rubifolide (9), lopholide (10), deoxylophotoxin (11), and the lophotoxin analogues 12 and 13. The structures of the new metabolites have been established by spectroscopic techniques and chemical correlation. The in vitro cytotoxicity has been tested against three tumor cell lines.