Evaluation of a New Preserved Latex Antigen for the Sero-Diagnosis of Rheumatoid Arthritis
1964; BMJ; Volume: 23; Issue: 6 Linguagem: Inglês
10.1136/ard.23.6.485
ISSN1468-2060
Autores Tópico(s)Parasite Biology and Host Interactions
ResumoSerological procedures useful for the detection of rheumatoid factors, utilizing polystyrene latex particles, have become well established and show a reasonably good degree of specificity and sensitivity (Mayne and Mathieson, 1961; Plotz and Singer, 1956; Vaughan, 1959).The use of these tests has been reviewed by Singer (1961) andWaller, Decker, Toone, andIrby (1961).The tests have also been found of value in studying patients with nonrheumatic diseases (Atwater and Jacox, 1963; Caplan, 1963; Dresner and Trombly, 1959; Howell, Malcolm, and Pike, 1960).Many modifications of the original Singer and Plotz Fraction II Latex Particle (F-IT L.P.) method (Singer and Plotz, 1956) have been reported, both slide and test tube (Bird and Burr, 1962; Rheins, McCoy, Buehler, and Burrell, 1957a; Singer and Plotz, 1958a, b).The F-TI L.P. procedure uses polystyrene latex particles (Dow, 0 81 ,t in diameter) sensitized with human gamma globulin (Fraction TI) in an alkaline buffer.Rheins, McCoy, Burrell, and Buehler (1957b) showed that gamma globulin from seven animal species, including bovine, could be used in place of
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