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Preparation, 195Pt NMR spectra and biological activity of platinum(IV) complexes with dipeptides

1999; Elsevier BV; Volume: 73; Issue: 1-2 Linguagem: Inglês

10.1016/s0162-0134(98)10084-3

1873-3344

Masatoshi Watabe, Takao Kobayashi, Takako Kawahashi, Ayako Hino, Toshihiko Watanabe, Takeshi Mikami, Tatsuji Matsumoto, Masuko Suzuki,

Organometallic Compounds Synthesis and Characterization

Three dipeptide complexes of the form K[Pt(IV)(dipep)Cl(OH)2] and four dipeptide complexes of the form K[Pt(IV)-(Hdipep)Cl2(OH)2] were newly prepared. The 195Pt NMR peaks of the K[Pt(IV) (dipep) Cl(OH)2] complexes appeared at about 1200 ppm and these chemical shifts were about 3150 ppm downfield compared with those of the K[Pt(II)(dipep)Cl] complexes. The chemical shifts of the K[Pt(IV)(Hdipep)Cl2(OH)2] complexes were at about 900 ppm, i.e., about 3050 ppm downfield compared with those of the K[Pt(II)(Hdipep)Cl] complexes. The H[Pt(IV)(Hdigly)Cl2(OH)2] and K[Pt(IV)(Hdigly)Cl2(OH)2] complexes inhibited the growth of C. albicans at a more diluted concentration than cisplatin at 1 μg/ml, but the platinum complexes only weakly inhibited the growth of these cells compared with the cisplatin-inhibited growth of Meth-A and Hep-2 cells at 10 μg/ml. These results suggested that the platinum complexes selectively inhibited the growth of fungal cells.