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Radiation Therapy for Prostate Cancer Increases Subsequent Risk of Bladder and Rectal Cancer: A Population Based Cohort Study

2008; Lippincott Williams & Wilkins; Volume: 180; Issue: 5 Linguagem: Inglês

10.1016/j.juro.2008.07.038

1527-3792

Alan M. Nieder, Michael P. Porter, Mark S. Soloway,

Bladder and Urothelial Cancer Treatments

No AccessJournal of UrologyAdult Urology1 Nov 2008Radiation Therapy for Prostate Cancer Increases Subsequent Risk of Bladder and Rectal Cancer: A Population Based Cohort Study Alan M. Nieder, Michael P. Porter, and Mark S. Soloway Alan M. NiederAlan M. Nieder Department of Urology, University of Miami Miller School of Medicine, Miami, Florida More articles by this author , Michael P. PorterMichael P. Porter Departments of Urology & Epidemiology, University of Washington and the VA Puget Sound Health Care System, Seattle, Washington More articles by this author , and Mark S. SolowayMark S. Soloway Department of Urology, University of Miami Miller School of Medicine, Miami, Florida More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2008.07.038AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Pre-prostate specific antigen era series demonstrated an increased risk of bladder cancer and rectal cancer in men who received radiotherapy for prostate cancer. We estimated the risk of secondary bladder cancer and rectal cancer after prostate radiotherapy using a contemporary population based cohort. Materials and Methods: We identified 243,082 men in the Surveillance, Epidemiology and End Results database who underwent radical prostatectomy or radiotherapy for prostate cancer between 1988 and 2003. We estimated the incidence rate, standardized incidence ratio and age adjusted incidence rate ratio of subsequent bladder cancer and rectal cancer associated with radical prostatectomy, external beam radiotherapy, brachytherapy, and a combination of external beam radiotherapy and brachytherapy. Results: The relative risk of bladder cancer developing after external beam radiotherapy, brachytherapy and external beam radiotherapy-brachytherapy compared to radical prostatectomy was 1.88, 1.52 and 1.85, respectively. Compared to the general United States population the standardized incidence ratio for bladder cancer developing after radical prostatectomy, external beam radiotherapy, brachytherapy and external beam radiotherapy-brachytherapy was 0.99, 1.42, 1.10 and 1.39, respectively. The relative risk of rectal cancer developing after external beam radiotherapy, brachytherapy and external beam radiotherapy-brachytherapy compared to radical prostatectomy was 1.26, 1.08 and 1.21, respectively. The standardized incidence ratio for rectal cancer developing after radical prostatectomy, external beam radiotherapy, brachytherapy and external beam radiotherapy-brachytherapy was 0.91, 0.99, 0.68 and 0.86, respectively. Conclusions: Men who receive radiotherapy for localized prostate cancer have an increased risk of bladder cancer compared to patients undergoing radical prostatectomy and compared to the general population. The risk of rectal cancer is increased in patients who receive external beam radiotherapy compared to radical prostatectomy. Patients should be counseled appropriately regarding these risks. References 1 : Cancer statistics, 2007. CA Cancer J Clin2007; 57: 43. 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Google Scholar © 2008 by American Urological AssociationFiguresReferencesRelatedDetailsCited byBrant A, Lewicki P, Wu X, Sze C, Johnson J, Basourakos S, Arenas-Gallo C, Shoag D, Barbieri C, Zaorsky N and Shoag J (2022) Impact of Left-Digit Age Bias in the Treatment of Localized Prostate CancerJournal of Urology, VOL. 208, NO. 5, (997-1006), Online publication date: 1-Nov-2022.Blackwell R, Kandabarow A, Gupta G, Harkenrider M, Quek M and Flanigan R (2018) Long-term Incidence of Hematuria, Urethral Stricture and Bladder Cancer after Radiation Therapy for Prostate CancerUrology Practice, VOL. 2, NO. 6, (349-358), Online publication date: 1-Nov-2015.Meeks J, Kern S, Dalbagni G, Eastham J and Sandhu J (2018) The Prevalence of Persistent Prostate Cancer after Radiotherapy Detected at Radical Cystoprostatectomy for Bladder CancerJournal of Urology, VOL. 191, NO. 6, (1760-1763), Online publication date: 1-Jun-2014.Yee D, Shariat S, Lowrance W, Sterbis J, Vora K, Bochner B, Donat S, Herr H, Dalbagni G and Sandhu J (2018) Impact of Previous Radiotherapy for Prostate Cancer on Clinical Outcomes of Patients With Bladder CancerJournal of Urology, VOL. 183, NO. 5, (1751-1756), Online publication date: 1-May-2010. Volume 180Issue 5November 2008Page: 2005-2010 Advertisement Copyright & Permissions© 2008 by American Urological AssociationKeywordsradiotherapyrectal neoplasmsurinary bladder neoplasmsprostatic neoplasmsprostatectomyMetricsAuthor Information Alan M. Nieder Department of Urology, University of Miami Miller School of Medicine, Miami, Florida More articles by this author Michael P. Porter Departments of Urology & Epidemiology, University of Washington and the VA Puget Sound Health Care System, Seattle, Washington More articles by this author Mark S. Soloway Department of Urology, University of Miami Miller School of Medicine, Miami, Florida More articles by this author Expand All Advertisement PDF downloadLoading ...