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A case of azoospermia in a bull carrying a Y-autosome reciprocal translocation

2001; Karger Publishers; Volume: 95; Issue: 3-4 Linguagem: Inglês

10.1159/000059349

1424-8581

L. Iannuzzi, L. Molteni, G.P. Di Meo, A. de Giovanni, A. Perucatti, G. Succi, D. Incarnato, A. Eggen, E.P. Cribiu,

Genetic Mapping and Diversity in Plants and Animals

During normal cytogenetic investigations on the Chianina cattle (BTA) breed, a normal looking young bull was found to carry an abnormal Y chromosome which was a product of a reciprocal translocation between chromosomes Y and 9. This was revealed by both CBA- and RBG-banding techniques and was clearly confirmed by FISH-mapping analysis with IDVGA50 (which paints the complete Yq arm in a normal Y), as well as with AMD1, CGA, IGF2R (mapping to BTA9q16, BTA9q22 and BTA9q27-->q28, respectively) and SRY (mapping to normal BTAYq23). Analysis on sperm from four different samples revealed azoospermia in the carrier, indicating that the rcp(Y;9) induces sterility in the bull.