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Benzofuran-Based Hybrid Compounds for the Inhibition of Cholinesterase Activity, β Amyloid Aggregation, and Aβ Neurotoxicity

2008; American Chemical Society; Volume: 51; Issue: 10 Linguagem: Inglês

10.1021/jm8002747

1520-4804

Stefano Rizzo, Céline Rivière, Lorna Piazzi, Alessandra Bisi, Silvia Gobbi, Manuela Bartolini, Vincenza Andrisano, Fabiana Morroni, Andrea Tarozzi, Jean‐Pierre Monti, Angela Rampa,

Alzheimer's disease research and treatments

The complex etiology of Alzheimer's disease (AD) prompts scientists to develop multitarget strategies to combat causes and symptoms. We therefore designed, synthesized, and tested new hybrid molecules linking a benzofuran ring to a N-methyl-N-benzylamine through a heptyloxy chain, affording a series of potential multifunctional drugs for AD. The cholinesterase inhibitory activity was extended to the inhibition of Aβ fibril formation for 1, 3, and 5. Compound 3 showed an additional neuroprotective effect.