Portal de Periódicos da CAPES

Artigo Acesso aberto Produção Nacional Revisado por pares

BIBTEX RIS

Fish Balistes capriscus skin extract-induced relaxation in mesenteric arterial bed of rat

2003; Elsevier BV; Volume: 88; Issue: 2-3 Linguagem: Inglês

10.1016/s0378-8741(03)00225-3

1872-7573

Lissandra Souto Cavalli, P.L. Possette, B Schmidt, Cleber Dario Pinto Kruel, Marcella Daruge Grando, Eliana Badiale–Furlong, Marta Regina Cezár-Vaz, Daniela M. Barros, Ana Luiza Muccillo‐Baisch,

Neurobiology and Insect Physiology Research

The vasorelaxing activity of the aqueous extract of fish Balistes capriscus skin (AEBc) on mesenteric arterial bed (MAB) of rats was studied. The bolus injections of AEBc (bolus of 5.1, 10.2, 20.5, and 41.1 mg) significantly inhibited, in a concentration-dependent manner, the maximal contractile response induced by methoxamine (30 μM) in MAB. The vasodilatation action of AEBc is not mediated through β-adrenoceptors or cyclo-oxigenase, since it was not affected by propranolol (20 μM) or diclofenac sodium (3 μM). The vasodilator response induced by subsequent addition of AEBc Balistes capriscus in bolus was significantly reduced in water infusion for endothelium removal. Treatment with an inhibitor of NO synthase (l-NAME, 10 μM) decreased AEBc effect. The guanylate cyclase inhibitor methylene blue (MB, 100 μM) had no significant effect on AEBc-induced vasodilatation. These results suggest that the vasorelaxing effect of AEBc is mediated by endothelium-dependent (NO/EDRF) and endothelium-independent neurally induced vasorelaxation from nonadrenergic and noncholinergic nerves (NO).