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Expression and role of DJ-1 in leukemia

2008; Elsevier BV; Volume: 375; Issue: 3 Linguagem: Inglês

10.1016/j.bbrc.2008.08.046

1090-2104

Hang Liu, Min Wang, Min Li, Donghai Wang, Qing Rao, Yang Wang, Zhifang Xu, Jianxiang Wang,

Cancer Mechanisms and Therapy

DJ-1 is a multifunctional protein that has been implicated in pathogenesis of some solid tumors. In this study, we found that DJ-1 was overexpressed in acute leukemia (AL) patient samples and leukemia cell lines, which gave the first clue that DJ-1 overexpression might be involved in leukemogenesis and/or disease progression of AL. Inactivation of DJ-1 by RNA-mediated interference (RNAi) in leukemia cell lines K562 and HL60 resulted in inhibition of the proliferation potential and enhancement of the sensitivity of leukemia cells to chemotherapeutic drug etoposide. Further investigation of DJ-1 activity revealed that phosphatase and tensin homolog (PTEN), as well as some proliferation and apoptosis-related genes, was regulated by DJ-1. Thus, DJ-1 might be involved in leukemogesis through regulating cell growth, proliferation, and apoptosis. It could be a potential therapeutic target for leukemia.