Syntheses and insulin-like activity of phosphorylated galactose derivatives
1993; Elsevier BV; Volume: 240; Linguagem: Inglês
10.1016/0008-6215(93)84177-8
ISSN1873-426X
AutoresHugo-Norberto Caro, Manuel Martín‐Lomas, Manuel Bernabé,
Tópico(s)Enzyme Production and Characterization
ResumoThe syntheses of the poly-phosphorylated galactosides 6, 8, 10, 13, 16, and 20, isolated as sodium salts, have been performed. The non-phosphorylated disaccharide 17 and trisaccharide 21 have been prepared via glycosylation of the 2-(trimethylsilyl)ethyl galactosides 3 and 2, respectively, and subsequent complete deprotection. Preliminary insulin-like activity of the phosphorylated derivatives is reported.
Referência(s)