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Determination of surface properties and flow characteristics of salbutamol sulphate, before and after micronisation

1998; Elsevier BV; Volume: 172; Issue: 1-2 Linguagem: Inglês

10.1016/s0378-5173(98)00179-3

1873-3476

Jane C. Feeley, P. York, B. S. Sumby, H. Dicks,

Phase Equilibria and Thermodynamics

Inverse gas chromatography (IGC) was employed to characterise the surface thermodynamic properties of two nominally equivalent batches of salbutamol sulphate and to highlight any surface energetic changes induced on micronisation. A powder flow avalanching analyser was used to probe the relationship between powder flow and the surface energetic properties. The results obtained demonstrate the potential of these techniques to detect and quantify differences in powder samples, before and after micronisation. They also indicate that surface energy differences detected by IGC can be related to important secondary processing properties such as powder flow.