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BIBTEX RIS

Influence of misonidazole on the radiosensitivity of a human melanoma in nude mice: Time-dependent increase in surviving fraction

1979; Elsevier BV; Volume: 5; Issue: 4 Linguagem: Inglês

10.1016/0360-3016(79)90811-3

ISSN

1879-355X

Autores

Marcelle Guichard, Frédérique de Langen-Omri, Edmond-Philippe Malaise,

Tópico(s)

bioluminescence and chemiluminescence research

Resumo

Using an in vitro colony method, we tested the effect of 1 tug/g misonidazole on a human melanoma transplanted into nude mice.The enhancement ratios were 1.6 when the cells were plated immediately after irradiation and 2.0 when plating was done after a delay of 6 hr.Whereas repair of potentially lethal damage (PLD) was demonstrated in cells without misonidazole, with the drug the surviving fraction was the same immediately or 6 hr after irradiation.Our interpretation of this finding is discussed.

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