SUPPRESSION OF HEPATITIS B ANTIBODY SYNTHESIS BY FACTOR MADE BY T CELLS FROM CHRONIC HEPATITIS B CARRIERS
1988; Elsevier BV; Volume: 331; Issue: 8581 Linguagem: Inglês
10.1016/s0140-6736(88)91119-1
ISSN1474-547X
AutoresKatsumi Yamauchi, Shue‐Shian Chiou, Toshimi Nakanishi, Hiroshi Obata,
Tópico(s)vaccines and immunoinformatics approaches
ResumoMononuclear cells taken from subjects who had been immunised with hepatitis B vaccine could be stimulated by pokeweed mitogen plus hepatitis B surface antigen to synthesise antibody to hepatitis B surface antigen in vitro. Such synthesis was suppressed by supernatants of cultures of T cells from hepatitis B surface antigen carriers. The suppressor activity of this soluble factor in the supernatants was specific for anti-HBs since it did not affect production of polyclonal immunoglobulins or specific antibody to tetanus toxoid and since its effect was completely absorbed by a hepatitis B surface antigen column. The suppressor factor was made by T-cell cultures but not by non-T-cell cultures. T-cells for 13 out of 15 carriers produced this factor.
Referência(s)