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Prevalence of Antibodies to Lymphadenopathy-Associated Retrovirus in African Patients with AIDS

1984; American Association for the Advancement of Science; Volume: 226; Issue: 4673 Linguagem: Inglês

10.1126/science.6238406

1095-9203

Françoise Brun‐Vézinet, C. Rouzioux, Luc Montagnier, S. Chamaret, J Gruest, Françoise Barré‐Sinoussi, Diego Geroldi, Jean‐Claude Chermann, Joseph B. McCormick, S. W. Mitchell, Peter Piot, H. Taelman, Kapita Bila Mirlangu, Odio Wobin, Mbendi N. Miazebo P., Patrick Kayembé, Chris H. Bridts, J. Desmyter, Fred M. Feinsod, Thomas C. Quinn,

HIV Research and Treatment

The presence of antibodies to lymphadenopathy-associated retrovirus (LAV) was determined by a radioimmunoprecipitation assay and by an enzyme-linked immunosorbent solid assay of sera from Zairian patients with the acquired immune deficiency syndrome (AIDS) in 1983. Thirty-five of 37 patients (94 percent) and 32 of 36 patients (88 percent), respectively, were seropositive by the two tests. In a control group of 26 patients, six (23 percent) showed positive results in these tests. Of these six control patients, five had clinically demonstrable infectious diseases and a low ratio of T4 to T8 lymphocytes. In addition, sera collected from a control group of Zairian mothers in 1980 were positive for LAV in 5 of 100 cases. Other serologic data suggest that LAV was present as early as 1977 in Zaire.