Buccally Administered Streptokinase
1958; Massachusetts Medical Society; Volume: 258; Issue: 22 Linguagem: Inglês
10.1056/nejm195805292582201
ISSN1533-4406
AutoresIrving Innerfield, Harold Shub, Linn J. Boyd,
Tópico(s)Platelet Disorders and Treatments
ResumoTHE anti-inflammatory effect of parenterally given proteases has evoked considerable clinical interest. In a recent review article Moser1 termed enzyme therapy "a new avenue of therapeutic approach to the problems of thromboembolism and inflammation." According to Kramer and de Madeiros,2 "numerous contributions have proven the value of enzymes in edema, cellulitis and particularly in hemorrhagic extravasations in the tissues."Several workers have investigated the possibility that the anti-inflammatory effect of proteolytic enzymes is due, in part, to their effect on tissue permeability.3 , 4 Indeed, the addition of streptokinase tended to restore permeability after reduction in the permeability of connective tissue by . . .
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