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COX 2 inhibitors can affect the stomach lining

1999; BMJ; Volume: 319; Issue: 7224 Linguagem: Inglês

10.1136/bmj.319.7224.1518

0959-8138

D. Josefson,

Colorectal Cancer Treatments and Studies

A new class of analgesics designed to be less ulcerogenic than traditional non-steroidal anti-inflammatory drugs may not protect the gastric lining after all, according to a University of California study (Nature Medicine 1999;5:1415-23, 1348-9). Their ulcerogenic effect may stem from their antiangiogenic properties, and as such they may be useful anticancer drugs. The analgesics, agents known as selective cyclo-oxygenase-2 (COX 2) inhibitors, were specifically designed to be less harmful to the gastric mucosal …