Serotonin receptor mRNA expression in rat dorsal root ganglion neurons
2003; Elsevier BV; Volume: 337; Issue: 3 Linguagem: Inglês
10.1016/s0304-3940(02)01256-9
ISSN1872-7972
AutoresR. Nicholson, Jack A. Small, A. K. Dixon, David Spanswick, K. Lee,
Tópico(s)Neuropeptides and Animal Physiology
ResumoIn the present study, we have used in situ hybridization to examine the distribution of serotonin (5-HT) receptors in rat dorsal root ganglion (DRG) neurons. Within DRG neurons, mRNAs for 5-HT1B, 5-HT1D, 5-HT2A, 5-HT2B, 5-HT3B and 5-HT4 receptors were readily detected in small ( 45 μm) diameter neurons. In contrast mRNAs for 5-HT1A, 5-HT1E, 5-HT2C, 5-HT5A, 5-HT5B, 5-HT6 and 5-HT7 receptors were undetectable in these neurons. The present study provides an insight into the molecular profile of 5-HT receptor subtypes in neurons responsible for modulating sensory information.
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