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First Asymmetric Total Syntheses of Fawcettimine-Type Lycopodium Alkaloids, Lycoposerramine-C and Phlegmariurine-A

2009; American Chemical Society; Volume: 11; Issue: 23 Linguagem: Inglês

10.1021/ol902437t

1523-7060

Atsushi Nakayama, Noriyuki Kogure, Mariko Kitajima, Hiromitsu Takayama,

Traditional and Medicinal Uses of Annonaceae

A successful asymmetric total synthesis of lycoposerramine-C involving such key steps as a cobalt-mediated Pauson−Khand reaction and vinyl Claisen rearrangement and its biomimetic transformation to phlegmariurine-A are described.