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The effects of nitric oxide on the immune response during giardiasis

2010; Elsevier BV; Volume: 14; Issue: 6 Linguagem: Inglês

10.1016/s1413-8670(10)70119-7

1678-4391

Wander Rogério Pavanelli, Fredy R. S. Gutierrez, Jean Jerley Nogueira da Silva, Ivete Conchon‐Costa, Maria Claudia Noronha Dutra de Menezes, Francisco José de Oliveira, Eiko Nakagawa Itano, Maria Angélica Ehara Watanabe,

Neuroscience of respiration and sleep

Nitric oxide (NO) is a free radical synthesized from L-arginine by different isoforms NO-synthases. NO possesses multiple and complex biological functions. NO is an important mediator of homeostasis, and changes in its generation or actions can contribute or not to pathological states. The knowledge of effects of NO has been not only important to our understanding of immune response, but also to new tools for research and treatment of various diseases. Knowing the importance of NO as inflammatory mediator in diverse infectious diseases, we decided to develop a revision that shows the participation/effect of this mediator in immune response induced against Giardia spp. Several studies already demonstrated the participation of NO with microbicidal and microbiostatic activity in giardiasis. On the other hand, some works report that Giardia spp. inhibit NO production by consuming the intermediate metabolite arginine. In fact, studies in vitro showed that G. lamblia infection of human intestinal epithelial cells had reduced NO production. This occurs due to limited offer of the crucial substrate arginine (essential aminoacid for NO production), consequently reducing NO production. Therefore, the balance between giardial arginine consumption and epithelial NO production could contribute to the variability of the duration and severity of infections by this ubiquitous parasite.