Portal de Periódicos da CAPES

Neural Crest Cells Contribute to Normal Aorticopulmonary Septation

1983; American Association for the Advancement of Science; Volume: 220; Issue: 4601 Linguagem: Inglês

10.1126/science.6844926

1095-9203

Margaret L. Kirby, Thomas F. Gale, Donald Stewart,

Aortic Disease and Treatment Approaches

By analyzing the hearts of quail-chick chimeras, it was found that neural crest cells at the level of occipital somites 1 to 3 migrate to the region of the aorticopulmonary septum. Bilateral removal of this neural crest population prior to migration causes malformation of the aorticopulmonary septum resulting in common arterial outflow channels or transposition of the great vessels.