Systemic mastocytosis associated with acute myeloid leukemia: case report and implications for disease pathogenesis
2004; Elsevier BV; Volume: 114; Issue: 1 Linguagem: Inglês
10.1016/j.jaci.2004.02.042
ISSN1097-6825
AutoresLuís Escribano, Andrés C. García‐Montero, Rosa Núñez-López, Javier López‐Jiménez, Júlia Almeida, Aránzazu Prados, Alberto Órfão,
Tópico(s)Retinoids in leukemia and cellular processes
ResumoMastocytosis may be associated with clonal nonmast cell lineage hematologic diseases, including myelodysplastic syndromes, myeloproliferative disorders, and acute myeloid leukemia. Here we present a patient with the simultaneous diagnosis of mastocytosis and an acute myeloid leukemia, M2 subtype in the French-American-British classification, with t(8;21) carrying a population of immature mast cell precursors, and discuss this presentation in the context of a potential pathogenetic cellular link between this leukemia and mastocytosis.
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