The hypoglycemic effects of tryptamine in mice: mediation by 5-HT receptors
1988; Elsevier BV; Volume: 156; Issue: 2 Linguagem: Inglês
10.1016/0014-2999(88)90338-x
ISSN1879-0712
AutoresJun Yamada, Yumi Sugimoto, Ikuko Kimura, Naoko Takeuchi, Kazuyoshi Horisaka,
Tópico(s)Forensic Toxicology and Drug Analysis
ResumoThe effects of tryptamine on blood glucose levels were studied. Tryptamine induced significant hypoglycemia in mice. The hypoglycemia elicited by tryptamine was strongly antagonized by methysergide, an antagonist of both 5-HT1 and 5-HT2 receptors. A 5-HT2 receptor antagonist, ketanserin, partially inhibited the tryptamine-induced hypoglycemia. These results suggest that tryptamine-induced hypoglycemia is mediated by 5-HT1 and 5-HT2 receptors.
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